Metabolic
Regulation

Regulation of metabolic fluxes in vivo including glucose clamp and exercise protocols. Arterial and venous catheterization a week before experiments allow studies without stress. Intravital imaging and novel surgical preparations are available.

Body Weight
Regulation

Regulation of body weight from whole body to mitochondria. Metabolic and behavioral components of energy balance are measured with high precision and time resolution. Mouse bariatric and other surgical models are used to study weight loss.

Analytical
Resources

Specialized analytical techniques consist in four subcores: (1) Hormone Assay and Analytical Services, (2) Lipids, Lipoproteins, and Atherosclerosis, (3) Mouse Pathology, and (4) Metabolic Flux Analysis.

Surgical
Services

Specialized surgical procedures for indwelling catheters, CNS implantations, study of GI-liver function, and parabiosis. Development of new surgical procedures and surgical training are also available.

Expedited Phenotyping

Mice from these vendors do not require quarantine:

Jackson Labs
Harlan Teklad
Taconic Farms
Charles River Labs
National Cancer Institute
National Institute of Aging
UC Davis Mouse Biology Program

Courses & Education

Isotope Tracers in Metabolic Research: Principles and Practice of Kinetic Analysis (November 13-17, 2023)
Glucose Clamping the Conscious Mouse: A Laboratory Course Mouse Metabolic Phenotyping Center - Vanderbilt University Nashville, TN (October 2-6, 2023)
See JoVE Production on the Vanderbilt Clamp
MMPC Grant Programs

Our Mission

To advance research by providing novel experimental tools to the scientific community for phenotyping genetic mouse models related to diabetes, obesity, and other metabolic diseases.

Our Goals

Broaden the scope of techniques available to investigators
Standardize key methodologies
Expedite the completion of research
Compile a database for mouse models of diabetes

Latest News

Twitter Feed

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Recent Publications

Mitochondrial-targeted antioxidant attenuates preeclampsia-like phenotypes induced by syncytiotrophoblast-specific Gαq signaling December 1, 2023 Megan A Opichka
The Antioxidative Effects of Flavones in Hypertensive Disease November 25, 2023 Alexandria Porcia Haynes
Lipolysis supports bone formation by providing osteoblasts with endogenous fatty acid substrates to maintain bioenergetic status November 24, 2023 Ananya Nandy
Characterization of BRCA2 R3052Q variant in mice supports its functional impact as a low-risk variant November 19, 2023 Arun Prakash Mishra
3D reconstruction of murine mitochondria reveals changes in structure during aging linked to the MICOS complex November 14, 2023 Zer Vue
Exercise training adaptations in liver glycogen and glycerolipids require hepatic AMP-activated protein kinase in mice November 8, 2023 Curtis C Hughey
Dystonin modifiers of junctional epidermolysis bullosa and models of epidermolysis bullosa simplex without dystonia musculorum October 26, 2023 Thomas J Sproule
Restriction of Arginine Induces Antibiotic Tolerance in Staphylococcus aureus October 24, 2023 Jeffrey A Freiberg
Glucagon-like Peptide-1 Receptor Pathway Attenuates Platelet Activation in Aspirin-Exacerbated Respiratory Disease October 23, 2023 Dinah Foer
Turicibacterales protect mice from severe Citrobacter rodentium infection October 6, 2023 Kristen L Hoek
An early-life microbiota metabolite protects against obesity by regulating intestinal lipid metabolism October 5, 2023 Catherine D Shelton
Transcriptomic analysis of diabetic kidney disease and neuropathy in mouse models of type 1 and type 2 diabetes October 4, 2023 Sarah E Elzinga
Nectin-3 and shed forms of CSPG4 can serve as epithelial cell receptors for Clostridioides difficile TcdB September 25, 2023 Kevin O Childress
Oxidized Phospholipid oxPAPC Alters Regulatory T-Cell Differentiation and Decreases Their Protective Function in Atherosclerosis in Mice September 7, 2023 Brenna D Appleton
Unbalanced redox status network as an early pathological event in congenital cataracts September 7, 2023 Eloy Bejarano

MetabolicRegulation

Body WeightRegulation

Analytical Resources

SurgicalServices