Cardiovascular Pathophysiology Core
Director: Antonis K. Hatzopoulos, Ph.D.
Preston Research Building 357
Research Assistant: Lin Zhong, Ph.D.
The objective of the Cardiovascular Pathophysiology Core (CPC) is to provide investigators at Vanderbilt and outside institutions a cost-effective means to accurately assess cardiovascular phenotypes in mouse models of diabetes and metabolic disease. The CPC uses validated approaches and state-of-the-art instrumentation that allow for sensitive screening of phenotypic variations. For many studies, multiple measurements can be coordinated with the other Cores of the MMPC: for example, non-invasive serial echocardiographic and blood pressure determinations during a period of high-fat feeding or other environmental stress, measuring the metabolic response to exercise on a subset of mice, and histologic evaluation on sacrifice. The CPC also offers several surgical techniques to induce myocardial injury (infarction, aortic banding, and ischemia/reperfusion injury).