Metabolic Regulation Core

Director: Owen McGuinness, Ph.D.

Managing Director and Core Contact: Louise Lantier, Ph.D.

815 Light Hall

To view our list of services or submit a service request, please visit our Vanderbilt iLab core facility page.
If you would like a consultation for your study design prior to submitting a request or have any questions, please contact us.

Core Description:

The techniques necessary to study the impact of genetic, dietary or pharmacologic manipulations on metabolic and endocrine processes are difficult and specialized. Performing well-controlled metabolism experiments in mice is difficult due to their small size. The conscious mouse is studied free of stress (no handling, no restraint) based on measurements of catecholamine and corticosterone levels. Also see Surgical Services. The Aims of this Core are to:

  • Provide state-of-the-art services to assess the regulation of metabolic flux in vivo using a variety of glucose clamp and exercise protocols
  • Provide robust imaging technology to monitor the dynamics of cellular process
  • Train investigators in approaches to study metabolism in conscious unstressed mice

Subcore Tissue and In vivo Imaging
742 Light Hall
Director: Jenny Schafer, Ph.D.

Subcore Murine Pancreatic Islet Isolation Core (run through the Vanderbilt DRTC)
748 Preston Research Building
Director: Marcela Brissova, Ph.D.
Research Assistant: Anastasia Coldren